Evidence is too limited to rate Aluminum Sesquichlorohydrate for seborrheic dermatitis because it is mainly an underarm antiperspirant ingredient, not a facial or scalp treatment.

Small hyperhidrosis studies support its sweat-reducing role and found generally good tolerance in the tested underarm formulas, but aluminium salts can still itch or irritate through their acidic action. They are not fatty Malassezia nutrients, yet no direct seb derm evidence was found. Keep it to the intended body area and avoid applying it to broken, freshly shaved or actively inflamed skin unless the product directs otherwise.